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Studies on CBD and Post Traumatic Stress Disorder
Did you know that one pillar of post-traumatic stress disorder (PTSD) is an endocannabinoid deficiency? Researchers found people with PTSD had lower serum levels of anandamide, our “inner cannabis”, with the deficit causing chronic anxiety, fear extinction and aversive memory consolidation. Cannabidiol (CBD) enhances endocannabinoid tone—researchers say this is one promising way to treat PTSD.
Studies on CBD and Post Traumatic Stress Disorder
- The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD
- Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
- Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
- Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors
- CBD blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors
- Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis
- Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
- Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment
- The endocannabinoid system and extinction learning
- A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers
- Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
- Non-antidepressant long-term treatment in post-traumatic stress disorder
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system
- The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review
- CBD Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System
- Bidirectional Effects of CBD on Contextual Fear Memory Extinction
- CBD disrupts the consolidation of specific and generalized fear memories via dorsal hippocampus CB1 and CB2 receptors
- Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report
CBD Potential Treatment for PTSD and Specific Phobias, Study
A new study adds to the body of research indicating that a compound found in hemp and marijuana can be beneficial for treating PTSD and anxiety disorders.
Findings in a new study published by Frontiers in Pharmacology suggest that cannabidiol (CBD) is effective for treating post-traumatic stress disorder and specific phobias. The study, headed up by Chenchen Song of the University of Birmingham, found that CBD provides both acute and long-lasting effects to reduce fear memory.
CBD is a non-psychoactive cannabinoid found in the seeds, stalk and flowers of cannabis plants, including hemp and marijuana. CBD has yet to be FDA approved for any condition, but many studies indicate that the compound holds promising therapeutic benefits for a variety of conditions.
In the animal study, 10mg injections of CBD was found effective at reducing freezing behavior in rats that had been previously exposed to strong fear conditioning. The freeze response is a reaction to fear that is common among prey animals. The rats given CBD were significantly less likely to be fearful when put under the same conditions at a later date. The administering of CBD, Song and her research team explain, was effective at hindering the development of fear.
“In the more translationally-relevant stronger conditioning setting, CBD both acutely inhibited fear expression and enhanced extinction to produce longer lasting reductions in fear,” the study’s discussion reads. “These observations provide further support for the potential translational use of CBD in conditions such as posttraumatic stress disorder and specific phobias.”
Post-traumatic stress disorder (PTSD) is a mental condition most common in war veterans, but one that affects about 24.4 million Americans. The experiencing or witnessing of a traumatic event can lead to the development of PTSD, which can elicit severe anxiety, nightmares and uncontrollable flashbacks of the event. Previous studies also indicate that cannabinoids like CBD could be beneficial for managing PTSD’s symptoms. CBD has also shown to significantly reduce anxiety, cognitive impairment and discomfort in patients with social phobia. Its ability to reduce fear has been linked to its interaction with 5-HT1A receptors that are found in the central nervous system.
For comparison purposes, in Song’s study, some of the rats were given MK-801, a N-methyl-D-aspartate receptor antagonist known to impair the extinction of fear and thus increase freezing, and others were given D-cycloserine, a partial agonist which has shown to neither elevate or reduce freezing.
Unlike the findings in previous research, Song’s study did find that while CBD reduced freezing to near baseline levels in rats that had undergone strong fear conditioning, it impaired the extinction of fear in rats that had been exposed to weak fear conditioning.
Nineteen states have approved medical marijuana specifically for the treatment of PTSD, but none have yet approved it for anxiety. However, CBD oil derived from hemp is legal to import and buy in all 50 U.S. states. -Eve Ripley
- Eve is a writer specializing in cannabis education and editorials related to cannabis industry news.